Nanoemulsion Preparation Process Using High-Pressure Homogenizer
Nanoemulsions are fine oil-in-water or water-in-oil dispersions with droplet sizes typically below 200 nm, widely used in pharmaceutical, cosmetic, and functional food applications due to their high stability and solubilization capability. This guide provides a step-by-step workflow for nanoemulsion preparation using high-pressure homogenization for formulation and process development studies. 1. Why Use High-Pressure Homogenization for Nanoemulsions? High-pressure homogenization is a widely used technique for producing nanoemulsions at laboratory scale due to its strong droplet size reduction capability and good reproducibility. Compared with conventional emulsification methods such as ultrasonication or low-shear mixing, it provides: • Consistent nanoscale droplet size distribution • High reproducibility for formulation development • Improved physical stability of emulsions • Process parameters that can be linearly scaled with appropriate system design 2. Materials & Reagen...