Achieve Precision & Scale in Liposome Development with Genizer Extruders

 


In the fields of drug delivery, vaccine development, and genetic medicine, the precision and reproducibility of lipid nanoparticles (LNPs) and liposomes are paramount. Genizer's comprehensive portfolio of Liposome Extruders is engineered to meet this critical need, providing researchers and manufacturers with reliable, scalable, and compliant solutions from initial discovery to large-scale GMP production.

Why Choose Genizer Liposome Extruders?

Our extrusion technology is designed to transform heterogeneous lipid suspensions into homogeneous, unilamellar vesicles with narrow size distribution in a simple, one-step process. The core advantages that define our systems include:

  • Unmatched Size Control: Produce uniform liposomes and LNPs with precise diameters, typically achieved in just 3-10 passes through our defined pore-size, track-etched membranes.

  • Minimal to Zero Dead Volume: Maximize the yield of your valuable samples, from precious 0.25 mL research formulations to 200 L commercial batches, minimizing waste and cost.

  • Precise Temperature Control: Critical for handling heat-sensitive compounds, our systems (like the HandExtruder-RT and Jacketed Extruder) maintain optimal temperatures throughout the extrusion process to ensure lipid stability and integrity.

  • Scalability from Bench to Plant: Our range is designed for seamless scale-up. Start with the manual HandExtruder for small-scale R&D, move to the Online Extruder for pilot studies, and integrate the Multi Online System with sanitary pumps for full-scale GMP manufacturing.

  • Regulatory Compliance: Constructed from pharmaceutical-grade 316L stainless steel, our systems are easy to clean, sterilize, and are designed to comply with FDA and GMP sanitary standards, ensuring your process is audit-ready.

Explore the Genizer Extruder Portfolio:

  1. HandExtruder: The perfect entry point for basic research. Manually operated for samples from 0.25mL to 2.5mL, it offers minimal dead volume and optional temperature control for fast, easy formulation.

  2. Jacketed Liposome Extruder: Compressed air-driven for consistent pressure up to 500 psi. Its jacketed design provides excellent temperature control for processing sensitive drug and gene delivery formulations.

  3. Online Liposome Extruder: Engineered to be connected inline with a sanitary pump or homogenizer. It is ideal for continuous processing from pilot to production scale, offering no dead volume and full temperature control.

  4. Multi Online Liposome Extruders System: The solution for high-volume manufacturing. This system can control temperature and produce up to 200L per batch of therapeutic liposomes, such as those for anticancer drugs.

  5. Sanitary Pump Systems (NanoPump & PilotPump): The intelligent force behind the extrusion. These PLC-controlled pumps deliver highly accurate pressure and feature full monitoring capabilities, ensuring a reproducible and successful process.

Your Partner in Advanced Formulation

Whether you are developing the next breakthrough mRNA vaccine, a targeted cancer therapeutic, or a novel cosmetic delivery system, Genizer provides the extrusion technology you can trust. Our systems are built to deliver the precision, reliability, and compliance required to accelerate your product from the lab to the clinic.

Comments

Post a Comment

Popular posts from this blog

The advantage of Genizer liposome extruders

Image
 The Advantages of Genizer Liposome Extruders Genizer offers a comprehensive range of extruders suitable for researchers and manufacturers across all scales, from lab-scale  HandExtruder  and GJE-10mL/100mL models for small-scale research and development, to pilot-scale GJE-800mL/3000mL models for larger experiments and production runs, and the GOE-8L/25L extruder for large-scale commercial production. This means that regardless of the scale of the project, Genizer has an extruder that can meet the requirements.     Genizer extruders  can be easily connected to its own high-pressure homogenizers to create a powerful, integrated system. The intelligent control system of the homogenizers allows researchers and manufacturers to effortlessly set and adjust parameters, which enables precise control over critical factors such as temperature, pressure, and flow rate.  By ensuring that the processes are efficient and accurate, the intelligent control ...
Read more

Scaling with Genizer: High Pressure Homogenizers

Image
  At Genizer, we want our equipment to be with you every step of the way! That’s why we make equipment that squeezes into an academic lab all the way up to manufacturing. Here’s the   High-Pressure Homogenization  equipment that can take you all the way to capacity. HandGenizer For a more portable solution to high-pressure homogenization, we have the HandGenizer. Well suited to long-term storage, the HandGenizer is great in an academic R&D context. Its’ distinctive manual option and compact size set the HandGenizer apart, though it is best suited to small, even solutions like nanoemulsions. NanoGenizer Next is the NanoGenizer. Our most popular model, the NanoGenizer fits easily in a benchtop with a length under 28 inches (70 cm). The Nanogenizer has a max flow of 100mL/min, and a max pressure of 45,000 psi. Ideal for R&D, laboratory, and small-scale production. The NanoGenizer is quiet and easy to use. It also comes in Dual and Quad options for additional capacity...
Read more
Image
Liposome Processing: High-Pressure Homogenizer or Liposome Extruder  Choosing between a high-pressure homogenizer or a liposome extruder for your liposomes can be complicated. Both devices can process liposomes, but there advantages to each that will help you decide which is better for your application. High-Pressure Homogenizer Power:  Powering the NanoGenizer high-pressure homogenizer is simple. It’s electrically powered, and all you have to do is plug it into the wall. Speed:  The N anoGenizer has a faster flow rate than a liposome extruder. Efficiency:  While jamming occasionally happens with a liposome extruder, the NanoGenizer will not jam. Liposome Extruder Accuracy:  T he jacketed liposome extruders have a narrower size distribution of liposomes after processin g. Adjustable:  With a liposome extruder, you can adjust the membrane pore size and determine the diameter of liposomes after proc essing. Economical:  Our liposome extruders are more af...
Read more