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Showing posts from June, 2025

E. coli Model for Protein Amplification

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 Escherichia coli is a bacterium that most of us know first from recalls of foods like meat and lettuce. Although E. coli is a commensal (non-harmful) gut bacterium, the wrong circumstance and strain can make infection uncomfortable and dangerous. E. coli is gram negative, meaning it has a double-layered cell membrane that makes it more difficult to treat with antibiotics. Our homogenization equipment is regularly used to disrupt E. coli. In “Identification and Biosynthesis of pro-inflammatory sulfonolipids” authors Hou et al. use the NanoGenizer to break apart E. coli after using it for protein expression. Many other researchers have done the same (https://www.genizer.com/u_file/2206/file/6bffa6a456.pdf, https://www.genizer.com/u_file/2312/file/298f8a65e6.pdf , https://www.genizer.com/u_file/2312/file/3ca3c35d8a.pdf) What makes this common cause of diarrheal illnesses a welcome tool in so many research labs? First, we need to understand the research problem E. coli is being used...

Scaling with Genizer: High Pressure Homogenizers

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  At Genizer, we want our equipment to be with you every step of the way! That’s why we make equipment that squeezes into an academic lab all the way up to manufacturing. Here’s the   High-Pressure Homogenization  equipment that can take you all the way to capacity. HandGenizer For a more portable solution to high-pressure homogenization, we have the HandGenizer. Well suited to long-term storage, the HandGenizer is great in an academic R&D context. Its’ distinctive manual option and compact size set the HandGenizer apart, though it is best suited to small, even solutions like nanoemulsions. NanoGenizer Next is the NanoGenizer. Our most popular model, the NanoGenizer fits easily in a benchtop with a length under 28 inches (70 cm). The Nanogenizer has a max flow of 100mL/min, and a max pressure of 45,000 psi. Ideal for R&D, laboratory, and small-scale production. The NanoGenizer is quiet and easy to use. It also comes in Dual and Quad options for additional capacity...